性别：男
职称：副教授
政治面貌：中共党员
最高学历、学位：博士研究生
毕业院校：澳门大学
从事专业：动物营养与饲料科学
E-mail：loveskchen@163.com
研究方向
1.先天性免疫（巨噬细胞的功能调节）和获得性免疫（T细胞的功能调节）
2.免疫代谢重编程
3.开发针对畜禽免疫应激新型免疫疗法和营养干预手段
科研项目
1澳门特别行政区科学技术发展基金“中药小分子调控训练免疫治疗高尿酸血症的机制”（SKL-QRCM-OP24017），主持
2浙江大学重点实验室开放课题“线粒体-内质网偶联在氧化应激致仔猪肠道损伤中的作用研究”（KLMAN202304），主持
3湖北省教育厅科学技术研究计划中青年人才项目“SETDB1对仔猪Tregs免疫抑制功能的调控作用”，主持
代表性论文
1.Shaokui Chen, Ruixin Li, Yibo Chen, Chon-Kit Chou,Zhexuan Zhang, Yang Yang, Ping Liao,Qingqing Wang, and Xin Chen.Scutellarin enhances anti-tumor immune responses by reducing TNFR2-expressing CD4+Foxp3+regulatory T cells. Biomedicine & Pharmacotherapy, 2022; 151: 113187.
2.Shaokui Chen, Zibei Lin, Tianzhen He, Md Sahidul Islam, Long Xi, Ping Liao, Yang Yang, Ying Zheng, Xin Chen.Topical Application of Tetrandrine Nanoemulsion Promotes the Expansion of CD4+Foxp3+Regulatory T Cells and Alleviates Imiquimod-Induced Psoriasis in Mice. Front Immunol. 2022; 13: 800283.
3.Shaokui Chen, Zibei Lin, Long Xi, Ying Zheng, Qiong Zhou, Xin Chen. Differential role of TNFR1 and TNFR2 in the development of imiquimod-induced mouse psoriasis. J Leukoc Biol. 2021; 110(6): 1047-1055.
4.Shaokui Chen, Yulan Liu, Xiuying Wang, Haibo Wang, Shuang Li, Haifeng Shi, Huiling Zhu, Jing Zhang, Dingan Pi, Chien-An Andy Hu, Xi Lin, Jack Odle. Asparagine improves intestinal integrity, inhibits TLR4 and NOD signaling, and differently regulates p38 and ERK1/2 signaling in weanling piglets after LPS challenge. Innate Immun. 2016; 22: 577-587.
5.Tianzhen He, De Yang, Xiao-Qing Li, Mengmeng Jiang, Md Sahidul Islam,Shaokui Chen, Yibo Chen, Yang Yang, Chon-Kit Chou, Anna L Trivett, Joost J Oppenheim, Xin Chen. Inhibition of two-pore channels in antigen-presenting cells promotes the expansion of TNFR2-expressing CD4+Foxp3+regulatory T cells. Sci Adv. 2020; 6(40): eaba6584.
6.Tianzhen He, Shuoyang Liu,Shaokui Chen, Jingyi Ye, Xueqiang Wu, ZhaoxiangBian, Xin Chen. The p38 MAPK Inhibitor SB203580 Abrogates Tumor Necrosis Factor-Induced Proliferative Expansion of Mouse CD4 + Foxp3 + Regulatory T Cells. Front Immunol. 2018; 9: 1556.
7.Zibei Lin, Long Xi,Shaokui Chen, Jinsong Tao, Yan Wang, Xin Chen, Ping Li, Zhenping Wang, YingZheng. Uptake and trafficking of different sized PLGA nanoparticles by dendritic cells in imiquimod-induced psoriasis-like mice model. Acta Pharm Sin B. 2021; 11(4): 1047-1055.
8.Long Xi, Zibei Lin, Fen Qiu,Shaokui Chen, Ping Li, Xin Chen, Zhenping Wang, Ying Zheng. Enhanced uptake and anti-maturation effect of celastrol-loaded mannosylated liposomes on dendritic cells for psoriasis treatment. Acta Pharm Sin B. 2022; 12(1): 339-352.
9.Xiao Xu,Shaokui Chen, Haibo Wang, Zhixiao Tu, Shuhui Wang, Xiuying Wang, Huiling Zhu, Chunwei Wang, Jiadong Zhu, Yulan Liu. Medium-chain TAG improve intestinal integrity by suppressing toll-like receptor 4, nucleotide-binding oligomerisation domain proteins and necroptosis signalling in weanling piglets challenged with lipopolysaccharide. Br J Nutr. 2018; 119(9): 1019-1028.
10.Lin Zhang, Xiuying Wang,Shaokui Chen, Shuhui Wang, Zhixiao Tu, Guolong Zhang, Huiling Zhu, Xiangen Li, JianglinXiong, Yulan Liu. Medium-Chain Triglycerides Attenuate Liver Injury in Lipopolysaccharide-Challenged Pigs by Inhibiting Necroptotic and Inflammatory Signaling Pathways. Int J Mol Sci. 2018; 19(11): 3697.
11.Kan Xiao, Congcong Liu, Zhixiao Tu, Qiao Xu,Shaokui Chen, Yang Zhang, Xiuying Wang, Jing Zhang, Chien-An Andy Hu, Yulan Liu. Activation of the NF-κB and MAPK Signaling Pathways Contributes to the Inflammatory Responses, but Not Cell Injury, in IPEC-1 Cells Challenged with Hydrogen Peroxide. Oxid Med Cell Longev. 2020; 2020: 5803639.
12.Huiling Zhu, Yulan Liu,Shaokui Chen, Xiuying Wang, Dingan Pi, Weibo Leng, Feng Chen, Jing Zhang, Ping Kang. Fish oil enhances intestinal barrier function and inhibits corticotropin-releasing hormone/corticotropin-releasing hormone receptor 1 signalling pathway in weaned pigs after lipopolysaccharide challenge. Br J Nutr. 2016; 115(11): 1947-57.
13.Yulan Liu, Xiuying Wang, Huanting Wu,Shaokui Chen, Huiling Zhu, Jing Zhang, Yongqing Hou, Chien-An Andy Hu, Guolong Zhang. Glycine enhances muscle protein mass associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing TLR4 and NOD2 signaling in piglets challenged with LPS. Am J PhysiolRegulIntegr Comp Physiol. 2016; 311(2): R365-73.
14.陈少魁，刘玉兰，李权，等。脂多糖刺激对仔猪下丘脑-垂体肾上腺轴TLR4信号通路关键基因表达的影响,动物营养学报. 2014, 26(11): 3356-3361.
15.陈少魁，刘玉兰，李权，等。亚麻籽油对脂多糖刺激仔猪肝脏TLR4和NOD信号通路关键基因表达的影响,动物营养学报. 2016, 28(3): 891-898.
发明专利
1.Xin Chen, Ruixin Li,Shaokui Chen. Use of scutellarin in a medicament and a modulator for preventing or treating diseases, medicament, and modulator. United States Utility, UMPT175-2018, Granted.
