工作单位：中国农业科学院饲料研究所
职称：研究员（二级）
导师类别：博士生导师
政治面貌:党员
Email:zhouzhigang03@caas.cn
个人简介
周志刚，1974年出生，毕业于中国科学院水生生物研究所，获博士学位。中国农业科学院饲料所二级研究员，博士生导师，水产微生物与饲料创新团队首席，现代农业产业技术体系北京市渔业创新团队岗位专家，国家杰出青年基金项目获得者，中国农业科学院农科英才领军人才A类入选者。研究方向为水产动物营养与饲料科学/水产动物消化道微生物学。担任农业部饲用生物技术重点实验室主任。入选国家级人才计划，获“国家自然科学基金杰出青年基金”资助，水产学经典期刊《Aquaculture》副主编，2020-2021连续获得畜牧学中国高被引学者称号，H指数49。研究成果曾获第二十一届中国专利优秀奖（2019年）、福建省技术发明二等奖（2017年）、大北农科技成果奖一等奖（2015年）。获得授权发明专利38项（含3项PCT授权），发表学术论文220余篇，其中SCI收录120余篇，收录期刊包括Microbiome、iSciences、Gut Microbes、Environmental Microbiology（封面）、Journal of Nutrition（系列）等。兼任：中国畜牧兽医学会动物营养学分会常务理事、水产营养专题组主任、中国饲料工业协会生物饲料技术委员会副主任、第三届全国饲料评审委员会委员、科创中国微生物种业资源科技服务团成员。连续3年登上畜牧学领域的中国高被引学者榜单，入选2023年全球2%顶尖科学家榜单.
教育经历
1992.09--1996.06 华中农业大学水产学院，学士
1996.09--1999.06 华中农业大学水产学院，硕士研究生
1999.09--2002.06 中国科学院水生生物研究所，博士研究生
工作经历
2002.07-- 2002.12 中国农业科学院饲料研究所研究实习员
2003.01-2004.12 中国农业科学院饲料研究所助理研究员
2005.01--2009.12 中国农业科学院饲料研究所副研究员
（其间：2004.11--2006.11汕头大学海洋生物研究所博士后）
2010.01—现在 中国农业科学院饲料研究所研究员
2012.01--2012.06在美国德州农工大学农业与生命科学学院 访问学者
从事专业
水产养殖
研究方向
水产动物营养与饲料科学
水产动物消化道微生物学
科研项目
1.国家自然科学基金重点项目“肠道菌群调控养殖鱼类生长性状的机制研究”（32330110）
2.国家自然科学基金委国际(地区)合作与交流项目“从饲料到餐桌：水产养殖新发 次生生物危害分子机制研究” （32061133004）
3. 北京市现代农业产业技术体系北京市渔业创新团队岗位专家（BAIC09）
4. 国家自然科学基金国家杰出青年科学基金“鱼类消化道微生物与宿主互作”（31925038）
5. 国家自然科学基金面上项目 “鱼类肠道粘附空间类型影响乳杆菌抗病力的分子机制研究” （31872584）
6.国家重点基础研究发展计划（973计划）课题“基于群体感应新型微生物制剂的创制”（2015CB150605）
7. 国家自然科学基金面上项目“植物乳杆菌JCM 1149与短乳杆菌JCM 11 70 停喂后罗非鱼抗病力差异机制研究”（31572633）
8.中国农业科学院“院地”合作项目”中国水产动物消化道宏基因组计划”(2014-65 )
9.财政部、农业部中国农业科学院创新工程项目”水产动物饲料创新团队”
10.江苏省人才工作领导小组项目”高层次创新创业引进人才”(2013-321)
11.国家自然科学基金面上项目”植物乳杆菌JCM 1149与嗜酸乳杆菌JCM 1132饲喂斑马鱼益生机制比较研究”(31272672)
12.科技部“十二五”农村领域科技计划（子）课题”淡水养殖病虫害防治新型渔用生物酶制剂的研制与产品开发”(2012BAD25B0203)
13.农业部“948”项目”水产养殖暴发性流行病分子预警关键技术引进、创新与集成示范“（2012-Z8）
14.科技部科研院所技术开发研究专项“新型安全水产用微生物制剂几丁质酶的研制与开发“（2011EG134221）
15.科技部农业科技成果转化资金重点项目“新型饲用酶制剂N酰化高丝氨酸内酯酶的中试“（2010GB23260591）
16.国家自然科学基金面上项目“果寡糖影响罗非鱼肠道定植乳酸杆菌 分子生态的研究“（30972265）
代表性论文
1.Ming Li, Hui Liang, Hongwei Yang, Qianwen Ding, Rui Xia, Jie Chen, Wenhao Zhou, Yalin Yang, Zhen Zhang, Yuanyuan Yao, Chao Ran*,Zhigang Zhou*. Deciphering the gut microbiome of grass carp through multi-omics approach. Microbiome, 2024,12：2.
2.Yinyin Luan, Ming Li, Wei Zhou, Yuanyuan Yao, Yalin Yang, Zhen Zhang, Einar Ringø, Rolf Erik Olsen, Jihong Liu Clarke, Shouqi Xie,Kangsen Mai, Chao Ran*,Zhigang Zhou*.The fish microbiota: research progress and potential applications. Engineering,2023, 29: 137-146
3.Xingyu Chen, Shubin Liu, Qianwen Ding, Tsegay Teame, Yalin Yang, Chao Ran, Zhen Zhang*,Zhigang Zhou*.Research advances in the structure, function, and regulation of the gill barrier in teleost fish. Water Biology and Security, 2023, 2: 100139
4.Rui Xia, Qingshuang Zhang, Qiang Hao, Chao Ran, Yalin Yang, Aizhi Cao, Zhen Zhang*,Zhigang Zhou*. The direct and gut microbiota-mediated effects of dietary bile acids on the improvement of gut barrier in largemouth bass (Micropterus salmoides). Animal nutrition, 2023, 14: 32-42
5.Qingshuang Zhang, Hongwei Yang, Tsegay Teame, Chao Ran, Yalin Yang, Yuanyuan Yao, Qianwen Ding, Shubin Liu, Shengkang Li, Zhen Zhang*,Zhigang Zhou*.Immune disorders induced by improper use of dietary immunostimulants in aquatic animals: research progress and prospective solutions by targeting gut microbiota.Reviews in Aquaculture,2023,1-14
6.Hui Liang，Yu Li, Ming Li , Wei Zhou , Jie Chen , Zhen Zhang , Yalin Yang , Chao Ran *,Zhigang Zhou*. The effect and underlying mechanism of yeast ß-glucan on antiviral resistance of zebrafish against spring viremia of carp virus infection. Frontiers in Immunology,2022,13:1031962
7.Qianwen Ding, Qiang Hao, Qingshuang Zhang, Yalin Yang, Rolf Erick Olsen, Einar Ringo, Chao Ran, Zhen Zhang*,Zhigang Zhou*.DHA suppresses hepatic lipid accumulation via cyclin D1 in zebrafish. Frontiers in Nutrition, 2022,8:797510
8.Chao Ran, Mingxu Xie*, Jie Li, Yadong Xie, Yu Li, Wei Zhou, Yalin Yang, Zhen Zhang, Rolf Erik Olsen,Zhigang Zhou*. Dietary nucleotides alleviate hepatic lipid depositionviaexogenous AMP-mediatedAMPKactivationinzebrafish. TheJournal of Nutrition, 2021, 151(10): 2986-2996
9.Ding, Qian-wen, Zhang, Zhenm Li, Yu, Liu, Hong-Liang, Hao, Qiang, Yang, Ya-lin, Ringø, Einar, Erik Olsen, Rolf, Liu Clarke, Jihong, Ran, Chao*,Zhou, Zhi-Gang*.Propionate Induces Intestinal Oxidative Stress Via SOD2 Propionylation in Zebrafish. iScience, 2021, 24: 102515
10.Anran Wang, Zhen Zhang, Qianwen Ding, Yalin Yang, Jérôme Bindelle, Chao Ran,Zhigang Zhou*, Intestinal Cetobacterium and acetate modify glucose homeostasis via parasympathetic activation in zebrafish. Gut Microbes, 2021, 13(1): e1900996.
11.Juan Hua, Yuanyuan Yao, Yalin Yang , Chenchen Gao, Fengli Zhang,Rui Xia,
Chao Ran, Zheng Zhang, Jihong Liu Clarke,Zhigang Zhou*.Advances of intra-species molecular typing analysis of aqua feed probiotics. Reviews in Aquaculture, 2021, 13(1): 178-188.
12.Chao Ran, Yu Li, Xufa Ma, Yadong Xie, Mingxu Xie, Yuting Zhang, Wei Zhou, Yalin Yang, Zhen Zhang, Li Zhou, Kaijian Wei*,Zhigang Zhou*. Interactions between commensal bacteria and viral infection: insights for viral disease control in farmed animals. Science China·Life Sciences, 2021,64: 1437-1448
13.Yuan-Yuan Yao, Ya-Lin Yang*, Chen-Chen Gao, Feng-Li Zhang, Rui Xia, Dong Li, Juan Hu, Chao Ran, Zhen Zhang, Jihong Liu Clarke,Zhi-Gang Zhou*.Surface display system for probiotics and its application in aquaculture. Reviews in Aquaculture, 2020,12:2333–2350
14.Hongling Zhang, Chao Ran, Tsegay Teame, Qianwen Ding, Seyed Hossein Hoseinifar, Mingxu Xie, Zhen Zhang, Yalin Yang, Rolf Erik Olsen, Delbert M. Gatlin, Einar Ringø, Min Duan,Zhigang Zhou*. Research progress on gut health of farmed teleost fish: a viewpointconcerningthe intestinal mucosal barrier and the impact of its damage. Reviews in Fish Biology and fisheries, 2020 30:569-586
15.Zhen Zhang$, Chao Ran$, Qianwen Ding, Hongliang Liu, Mingxu Xie, Yalin Yang, Yadong Xie, Chenchen Gao, Hongling Zhang,Zhigang Zhou*,Risks of prebiotic polysaccharides in inducing gut dysbiosis and liver injury: a potential role of the HIF1α-antimicrobial peptides axis. Communications Biology,2019,2:274
16.Chao Ran ; Chubin Qin ; Mingxu Xie ; Jinxiong Zhang; Jie Li; YadongXie; Yibing Wang; Shuning Li; Lihui Liu; Xiaozhe Fu; Qiang Lin; Ningqiu Li; Mark R. Liles;Zhigang Zhou*. Aeromonas veronii and aerolysin are important for the pathogenesis of motile aeromonad septicemia in cyprinid fish, Environme ntal Microbiology,2018, 20(9): 3442~3456
17.Qianwen Ding ; Zhen Zhang ; Chao Ran; Suxu He; Yalin Yang; Zhenyu Du; Jinxiong Zhang;Zhigang Zhou*.The hepatotoxicity of palmitic acid in zebrafish involves the intestinal microbiota, Journal of Nutrition, 2018, 148(8): 1217~1228
18.X Guo ; C Ran ; Z Zhang; S He; M Jin;Z Zhou*.The growth promoting effect of dietary nucleotides in fish is associated with intestinal microbiota-mediated reduction in energy expenditure, Journal of Nutrition, 2017, (147): 781~788
19.C Ran ; J Hu ; W Liu ; Z Liu; S He; BCT Dan; NN Diem; EL Ooi ;Z Zhou*. Thymol and carvacrol affect hybrid tilapia through the combination of direct stimulation and an intestinal microbiota-mediated effect: insights from a germ-free zebrafish model, Journal of Nutrition, 2016, 146( 5): 1132~1140
20.Suxu He ; Quanmin Wang; Shuning Li; Chao Ran; Xiaoze Guo; Zhen Zhang;Zhigang Zhou*. Antibiotic growth promoter olaquindox increases pathogen susceptibility in fish by inducing gut microbiota dysbiosis, Science China· Life Sciences, 2017, 60(11): 1260~1270
21.Anran Wang ; Chao Ran ; Yanbo Wang; Zhen Zhang; Qianwen Ding; YalinYang; Rolf Erik Olsen; Einar Ringo; Jerome Bindelle;Zhigang Zhou*. Use of probiotics in aquaculture of China—a review of the past decade, Fish and Shellfish Immunology, 2019, (86): 734~755
22.Zhigang Zhou; Einar Ringø ; Rolf Erik Olsen; Seong Kyu Song.Dietary effects of soybean products on gut microbiota and immunity of aquatic animals: A review, Aquaculture Nutrition, 2018, 24(1): 644~665
23.A Wang ; C Ran ; E Ringø;Z Zhou*.Progress in fish gastrointestinal microbiota research, Reviews in Aquaculture, 2018, 10(3): 626~640
24.Seyed Hossein Hoseinifar ; Yun-Zhang Sun; Anran Wang;Zhigang Zhou*. Probiotics as means of diseases control in aquaculture, a review of current knowledge and future perspectives, Frontiers in Microbiology, 2018, 9: 2429
25.Chubin Qin ; Yadong Xie; Yibing Wang; Shuning Li; Chao Ran; Suxu He;Z higang Zhou*. Impact ofLactobacillus caseiBL23 on the host transcriptome, growth and disease resistance in larval zebrafish, Frontiers in Physiology, 2018, 9: 1245
26.W Liu ; W Wang; C Ran; S He; Y Yang;Z Zhou*.Effects of dietary scFOS and lactobacilli on survival, growth, and disease resistance of hybrid tilapia, Aquaculture, 2017, 470(1): 50~55
27.Chubin Qin ; Zhen Zhang; Yibing Wang; Shuning Li; Chao Ran; Jun Hu; Yadong Xie; Weifen Li ;Zhigang Zhou*.EPSP ofL. caseiBL23 protected against the infection caused by Aeromonas veronii via enhancement of immune response in zebrafish, Frontiers in Microbiology, 2017, 8
28.Yalin Yang; Juan Li; Xuewei Liu; Xingliang Pan; Junxiu Hou;Zhigang Zhou*. Improving extracellular production of Serratia marcescens lytic polysaccharide monooxygenase CBP21 and Aeromonas veronii B565 Chitinase Chi92 in Escherichia coli and their Synergism, AMB express, 2017, 7
29.Suxu He ; Chao Ran; Chubin Qin; Shuning Li; Hongling Zhang; Willem M.(#)de Vos; Einar Ringø;Zhigang Zhou*.Anti-infection effect of adhesive probiotic Lactobacillus in fish is correlated with their spatial distribution in the intestinal tissue, Scientific Reports, 2017, 7
30.Chao Ran ; Lu Huang; Jun Hu; Philippe Tacon; Suxu He; Zhimin Li; Yibing Wang; Zhi Liu; Li Xu; Yalin Yang;Zhigang Zhou*. Effects of dietary live and heat-inactive baker’s yeast on growth, gut health, and disease resistance of juvenile Nile hybrid tilapia under high rearing density, Fish & Shellfish Immunity, 2016, 56: 263~271
31.E Ringo ; ; JLG Vecino; S Wadsworth; J Romero; A Krogdahl; RE Olsen;Z Zhou; A Dimitroglou; A Foey; S Davies; M Owen; HL Lauzon; LL Martinsen; P de Schryver; P Bossier; S Sperstad; DL Merrifield, Effect of dietary components on the gut microbiota of aquatic animals. A never-ending story?, Aquaculture Nutrition, 2016, 22(2): 219~282
32.Z Liu ; H Wang ; ; N Naseer; F Xiang; B Kan; M Goulian;Z Zhou,et al..Differential thiol-based switches jump-start Vibrio cholerae pathogenesis, Cell Reports, 2016, 14(2): 347~354
33.Liu, Zhi ; Liu, Wenshu; Ran, Chao; Hu, Jun;Zhou, Zhigang*. Abrupt suspension of probiotics administration may increase host pathogen susceptibility by inducing gut dysbiosis, Scientific Reports, 2016, 6
34.X Pan ; Y Yang; X Liu; D Li; J Li; X Guo;Z Zhou*. Secretory expression of a heterologous protein, Aiio-AIO6BS, in Bacillus Subtilis via a non-cassical secretion pathway, Biochemical and Biophysical Research Communications (BBRC), 2016, 478(2): 881~886
35.J Hu ; C Ran; S He; Y Cao; B Yao; Y Ye ; X Zhang ;Z Zhou*. Dietar y microbial phytase exerts mixed effects on the gut health of tilapia: a possible reason for the null effect on growth promotion, British Journal of Nutrition, 2016, 115(11): 1958~1966
36.W Liu ; C Ran; Z Liu; Q Gao; S Xu; E Ringø; R Myklebust; Z Gu ;Z Zhou*. Effects of dietary Lactobacillus plantarum and AHL lactonase on the control of Aeromonas hydrophila infection in intilapia, Microbiology Open, 2016, 5(4): 687~699
37.Z Liu ; H Wang ; ; Y Sheng; N Naseer; B Kan; J Zhu,Z Zhou*.Thio l-based switch mechanism of virulence regulator AphB modulates oxidative stress response in Vibrio cholera, Molecular Microbiology, 2016, 102 (5): 939~949
38.L Huang ; C Ran ; S He; P Ren; J Hu; X Zhao;Z Zhou*.Effects of dietary Saccharomyces cerevisiae culture or live cells with Bacillus amyloliquefaciens spores on growth performance, gut mucosal morphology, hsp70 gene expression, and disease resistance of juvenile common carp (Cyprinus carpio), Aquaculture, 2015, 438(3): 33~38
39.C Ran ; L Huang ; Z Liu; L Xu; Y Yang; P Tacon; E Auclair; ,Z Zhou*.A comparison of the beneficial effects of live and heat-inactivated baker’s yeast on Nile tilapia: suggestions on the role and function of the secretory metabolites released from the yeast, PLos One, 2015, 10(12)
40.Y Yang ; J Xiong ; F Huo; W Miao; C Ran; Y Liu; J Zhang;Z Zhou*;Feng; M Wang; M Wang; L Wang; B Yao*.The genome of the Myxosorean Thelohanellus kitauei shows adaptatons to nutrient acquisition within its fish host, Genome Biology and Evolution,2014, 6(12): 3182~3198
41.Y Zhang ; Y Liu; Y Cao; S He; F Huo; C Qin; B Yao;Z Zhou*.Ringo, High-yield production of a chitinase fromAeromonas veroniiB565 as a potential feed supplement for warm-water aquaculture, Applied Microbiology and Biotechnology, 2014, 98(4): 1651~1662
42.C Qin; Y Zhang; W Liu; L Xu; Y Yang;Z Zhou*.Effects of chito-oligosaccharides supplementation on growth performance, intestinal cytokine expression, autochthonous gut bacteria and disease resistance in hybrid tilapia Oreochromis niloticus♀×Oreochromis aureus♂, Fish & Shellfish Immunology, 2014, 40(1): 267~274
43.W Liu; Y Yang; J Zhang; DM Gatlin; E Ringo;Z Zhou*.Effects of dietary microencapsulated sodium butyrate on growth, intestinal mucosal morphology, immune response and adhesive bacteria in juvenile common carp (Cyprinus carpio) pre-fed with or without oxidised oil , British Journal of Nutrition,2014, 112(1): 15~29
科技奖励
1. 高比活耐热N-酰基高丝氨酸内酯酶AiiA-AIO6及其编码基因与应用,中国专利优秀奖，2020年(排第1)
2. 水产健康养殖高效微生物制剂关键技术创新与应用, 福建省人民政府, 技术发明二等奖, 2018年(排第1)
3. 水产健康养殖关键生物制剂创制与应用, 北京大北农科技集团股份有限公司, 大北农科技奖成果奖一等奖，2015年（排第1）
发明专利
1.N-酰基高丝氨酸内酯酶及其生产方法与专用重组菌. 中国发明专利ZL200910238630.1
2.获取细菌16S rRNA基因的V3区核苷酸序列的方法及其专用引物. 中国发明专利 ZL201010114660.4
3.在酵母中高效表达N-酰基高丝氨酸内酯酶的DNA及其构建的工程菌. 中国发明专利ZL201010239510.6
4.N-乙酰高丝氨酸内酯酶-木聚糖酶融合蛋白及其编码基因和应用. 中国发明专利ZL201010251451.4
5.几丁质酶ChiCD3及其编码基因和应用. 中国发明专利ZL 201110092079.1
6.几丁质酶的四膜虫表达载体及其在表达几丁质酶中的应用. 中国发明专利ZL 201110430564.5
7.一种脂肪酶及其编码基因与应用. 中国发明专利ZL 201210059320.5
8.具有β-N-乙酰氨基葡萄糖苷酶活性的蛋白质及其编码基因和应用. 中国发明专利 ZL201210065384.6
9.几丁质酶CHI -X及其编码基因与应用. 中国发明专利ZL201210510998.0,
10.无菌斑马鱼的生产方法. 中国发明专利 ZL201310096246.9
11.Chi92蛋白的新用途以及表达Chi92蛋白的菌株. 中国发明专利ZL201310259571.2
12.一种三丁酸甘油酯的制备方法. 中国发明专利ZL201410279666.5
13.Chi92蛋白的新用途以及表达Chi92蛋白的菌株.日本专利特许第6355727号
14.一种高效分泌表达溶解性多糖单加氧酶CBP21的重组菌及其应用. 中国发明专利ZL201610236250.4
15.一套高效分泌表达异源蛋白的工程菌及其应用。中国发明专利ZL201610649512.X
16.一种防控水产养殖动物气单胞菌出血病的减毒活疫苗.中国发明专利201711138001.2
17.具有粘孢子虫孢子壁降解能力的几丁质酶及其编码基因. 中国发明专利ZL200910088808.9
18.一种三丁酸甘油酯的制备方法.印度授权专利号352231
19.一种防控水产养殖动物气单胞菌出血病的减毒活疫苗.日本授权发明专利特许第6971378号
20.一株具有降脂、抑炎、抗凋亡及抗病毒功能的水产益生菌与应用.中国发明专利202010134976.3
21.核酸酶At_NrnCM及其编码基因与应用，中国发明专利202011320304.8
22.一株水产饲用益生菌及其菌剂的制备方法，中国发明专利202110813315.8
23.一种构建具有降低肝脏脂肪积累且保护肠道屏障功能的基因工程菌的方法及应用. 中国发明专利ZL202110544436.7
24.一种提高草食性及杂食性水产动物健康和生长的预消化饲料.中国发明专利ZL202210552443.6
25.一种提高肉食性水产动物健康和生长的预消化饲料.中国发明专利ZL202210552442.1
26.植物乳杆菌CICC6240在消减水产品体内抗生素残留中的应用。中国发明专利ZL202211026125.2
学术专著
1. Seyed Hossein Hoeseinifar; Yun-Zhang Sun;Zhigang Zhou, (*) Chapter 7: Prebiotics and synbiotics. In. Diagonosis and control of diseases of fish and shellfish, John Wiley & Sons Ltd., 2017
2.Z Zhou; B Yao; J Romero; P Waines; E Ringo; M Emery; MR Liles; DL (#)(*) Merrifield, Chapter 5: Methodological approaches used to assess fish gastrointestinal communities, Wiley-Blackwell Publishing, 2014
